研究成果

近五年代表著作及成果

1.以新世代睡眠分析系統探討實習醫師值班造成的身心壓力 (Stress, 2012)

2.發現休息對於值夜班的護理人員睡眠相關自主神經功能有改善的效果 (Industrial Health, 2012)

3.本團隊開發新的人體睡眠自動判期的程式,其結果與睡眠技師判讀結果類似 (Clinical Neurophysiology, 2012)

4.呼吸頻率對於感壓反射的靈敏度之基礎研究 (Journal of Hypertension, 2012)

5.開發新世代的動物多訊號記錄系統 (Journal of Medical and Biological Engineering, 2012)

6.探討不同抗精神病藥物對於大鼠睡眠相關自主神經功能之影響 (Neuropsychobiology, 2012)

7.α1腎上腺素對於高血壓大鼠睡眠功能之影響 (American Journal of Hypertension, 2012)

8.中大腦動脈阻塞後長時間監控自主神經功能及睡眠型態之研究 (Autonomic Neuroscience-Basic and Clinical, 2012)

9.利用大鼠探討睡眠後半期易引起心血管事件之原因 (Journal of Sleep Research, 2012)

10.探討神經痛引發之睡眠相關心血管反應 (International Journal of Developmental Neuroscience, 2012)

11.2013年部分開發之儀器現已商品化、取得專利權以及應用於研究中

12.追蹤12個月的研究發現,特別是男性實習醫師,其心臟之副交感神經調節功能較弱且具憂鬱之症狀 (Psychophysiology, 2013);另亦發現實習醫師於輪值日時,其快速動眼期睡眠顯著的較長 (PLoS One, 2013)

13.透過電刺激延腦鼻端腹外側核可促進大鼠清醒 (Sleep Medicine, 2013)

14.發現暴露於寒冷環境中將使得晨間血壓驟升幅度提高,並此現象與睡眠後期之交感神經功能活性上升有關 (Sleep Medicine, 2014)

15.發現大鼠在安靜睡眠時 (等同於人類之非快速動眼期睡眠) 較弱的感壓反射調控、副交感神經活性,以及主動睡眠時 (等同於人類之快速動眼期睡眠) 較低的交感神經活性,皆於較小的血壓下降幅度有關 (Journal of Hypertension, 2014)

16.發現自覺入睡困難者其白天副交感神經活性較弱;而慢速 (0.1 Hz)定量呼吸訓練,可有效降心率及調升整體自律神經功能,同時並能有效改善客觀睡眠品質,特別是縮短入睡時間以及提升睡眠效度 (Psychophysiology, 2015)

17.失眠者的入睡時間與心跳變動有關 (Psychiatry Research, 2015)

18.探討人體老化過程中 (20-80歲) 心血管功能及睡眠型態之改變情形,目前發現50歲為一重要分水嶺,老化造成睡眠品質改變的問題有可能是由於自律神經功能退化所造成,而50歲之後睡眠品質不好與交感神經活性較高有關 (Age, 2016)

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相關研究著作

1. Fu, C. H., Yang, C. C. H., Lin, C. L. and Kuo, T. B. J.* (2008) Alteration of cardiovascular autonomic functions by vegetarian diets in postmenopausal women is related to LDL cholesterol levels. Chinese Journal of Physiology 51:100-105

2. Chen, C. L.*, Yi, C. H., Kuo, T. B. J. and Yang, C. C. H. (2008) Effect of acid suppression on gastric myoelectrical activity in GERD. Hepatogastroenterology 55:1353-1355

3. Yi, C. H., Chen, C. L.*, Kuo, T. B. J. and Yang, C. C. H. (2008) The effect of acid suppression on sleep and cardiac autonomic regulation in GERD. Hepatogastroenterology 55:1649-1652

Harnod, T., Yang, C. C. H., Hsin, Y. L., Wang, P. J., Shieh, K. R. and Kuo, T. B. J.* (2008) Heart rate variability in children with refractory generalized epilepsy. Seizure: European Journal of Epilepsy 17:297-301

4. Lai, I. C.*, Yang, C. C. H., Kuo, T. B. J., Wang, Y. C., and Shieh, K. R. (2008) Immediate impact of electroconvulsive therapy on cardiac autonomic function in schizophrenia: A preliminary study. Schizophrenia Research 100:353-355

5. Kuo, T. B. J., Shaw, F. Z., Lai, C. J., and Yang, C. C. H.* (2008) Asymmetry in sympathetic and vagal activities during sleep-wake transitions. Sleep 31:311-320

6. Li, J. Y.†, Kuo, T. B. J.†, Hsieh, S. S., and Yang, C. C. H.* (2008) Changes in electroencephalogram and heart rate during treadmill exercise in the rat. Neuroscience Letters 434:175-178

7. Yang, C. C. H., Yeh, I. T., Lai, H. Y., Chen, H. I., and Kuo, T. B. J.* (2008) Dynamic effects of respiration on aortic blood flow and its autonomic control in rats. Clinical and Experimental Pharmacology and Physiology 35:1294-1300

8. Wang, Y. C., Yang, C. C. H., Bai, Y. M., and Kuo, T. B. J.* (2008) Heart rate variability in schizophrenic patients switched from typical antipsychotic agents to amisulpride and olanzapine: 3-month follow-up. Neuropsychobiology 57:200-205

9. Chung, M. H., Chang, F. M., Yang, C. C. H., Kuo, T. B. J., and Hsu, N.* (2009) Sleep quality and morningness-eveningness of shift nurses. Journal of Clinical Nursing 18:279-284

10. Harnod, T., Yang, C. C. H., Hsin, Y. L., Wang, P. J., Shieh, K. R., and Kuo, T. B. J.* (2009) Heart rate variability in patients with frontal lobe epilepsy. Seizure: European Journal of Epilepsy 18:21-25

11. Chen, C. J.†, Kuo, T. B. J.†, Tseng, Y. J., and Yang, C. C. H.* (2009) Combined cardiac sympathetic excitation and vagal impairment in patients with non-organic erectile dysfunction. Clinical Neurophysiology 120:348-352

12. Kuo, T. B. J., Yang, C. C. H.*, and Huang, N. E. (2009) Quantification of Respiratory Sinus Arrhythmia Using Hilbert-Huang Transform. Advances in Adaptive Data Analysis 1:295-307

13. Kuo, T. B. J., and Yang, C. C. H.* (2009) Frequency domain analysis of electrooculogram and its correlation with cardiac sympathetic function. Experimental Neurology 217:38-45

14. Chung, M. H., Kuo, T. B. J., Hsu, N., Chu, H., Chou, K. R., and Yang, C. C. H.* (2009) Sleep and autonomic nervous system changes - enhanced cardiac sympathetic modulations during sleep in permanent night shift nurses. Scandinavian Journal of Work Environment and Health 35:180-187

15. Sun, T. B.*, Kuo, T. B. J., and Yang, C. C. H. (2009) Nonparallel cutaneous microcirculatory responses to pharmacologic alterations of systemic arterial pressure in rats. Microsurgery 29:319-325

16. Sun, T. B.*, Kuo, T. B. J., and Yang, C. C. H. (2009) Power spectral analysis of perfusion signals on free radial forearm flap transplantation in humans. Microsurgery 29:636-643

17. Chen, H. C., Yang, C. C. H., Kuo, T. B. J., Su, T. P., and Chou, P.* (2010) Gender differences in the relationship between depression and cardiac autonomic function among community elderly. International Journal of Geriatric Psychiatry 25:314-322

18. Kuo, H. K., Yang, C. C. H., Yu, Y. H., Tsai, K. T., Chen, C. Y.* (2010) Gender-specific association between self-reported sleep duration and falls in high-functioning older adults. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 65:190-196

19. Huang, Y. M., Yang, C. C. H., Lai, C. J., and Kuo, T. B. J.* (2010) Involvement of sympathetic function in the sleep-related change of gastric myoelectrical activity in rats. Journal of Sleep Research 19:192-200

20. Hsin, Y., Yang, C. C. H., Kuo, T. B. J., and Harnod, T.* (2010) Effects of chronic epilepsy on heart rate variability. Neural Regeneration Research 5:156-160

21. Lai, I. C., Yang, C. C. H., Kuo, T. B. J., and Shieh, K. R.* (2010) Transcranial magnetic stimulation for auditory hallucination in severe schizophrenia: partial efficacy and acute elevation of sympathetic modulation. Psychiatry and Clinical Neurosciences 64:333-335

22. Kuo, T. B. J., Lai, C. T., Hsu, F. C., Tseng, Y. J., Li, J. Y., Shieh, K. R., Tsai, S. C., and Yang, C. C. H.* (2010) Cardiac neural regulation oscillates with the estrous cycle in freely moving female rats: the role of endogenous estrogens. Endocrinology 151:2613-2621

23. Kuo, T. B. J.†, Li, J. Y.†, Hsieh, S. S. Y., Chen, J. J., Tsai, C. Y., and Yang, C. C. H.* (2010) Effect of aging on treadmill exercise induced theta power in the rat. Age 32:297-308

24. Chen, W. L., Tsai, T. H., Yang, C. C. H. and Kuo, T. B. J.* (2010) Acute effects of ephedra on autonomic nervous modulation in healthy young adults. Clinical Pharmacology and Therapeutics 88:39-44

25. Chen, W. L., Tsai, T. H., Yang, C. C. H. and Kuo, T. B. J.* (2010) Effects of ephedra on autonomic nervous modulation in healthy young adults. Journal of Ethnopharmacology 130:563-568

26. Chen, C. Y., Yang, C. C. H., Lin, Y. Y. and Kuo, T. B. J.* (2011) Locomotion-induced hippocampal theta is independent of visual information in rats during movement through a pipe. Behavioural Brain Research 216:699-704

27. Kuo, T. B. J., Yuan, Z. F., Lin, Y. S., Lin, Y. N., Li, W. S., Yang, C. C. H. and Lai, C. J.* (2011) Reactive oxygen species are the cause of the enhanced cardiorespiratory response induced by intermittent hypoxia in conscious rats. Respiratory Physiology and Neurobiology 175:70-79

28. Kung, Y. Y., Yang, C. C. H., Chiu, J. H. and Kuo, T. B. J.* (2011) The relationship of subjective sleep quality and cardiac autonomic nervous system in postmenopausal women with insomnia under auricular acupressure. Menopause 18: 638-645

29. Huang, Y. M., Yang, C. C. H., Lai, C. J. and Kuo, T. B. J.* (2011) The influence of autonomic interventions on the sleep-wake related changes in gastric myoelectrical activity in rats. Neurogastroenterology and Motility 23: 560-e208

30. Chen, S. Y., Yang, C. C. H., Kuo, T. B. J. and Harnod T.* (2011) Association of heart rate variability with clinical outcome in parkinsonian patients after subthalamic deep brain stimulation: A retrospective cohort study. Journal of the Formosan Medical Association 110:593-599

31. Kuo, T. B. J., Li, J. Y.†, Chen, C. Y., and Yang, C. C. H.* (2011) Changes in hippocampal theta activity during initiation and maintenance of running in the rat. Neuroscience 194:27-35

32. Chung, M. H., Kuo, T. B. J., Hsu, N., Chuo, K. R., Chu, H. and Yang, C. C. H.* (2011) Comparison of sleep-related cardiac autonomic function between rotating-shift and permanent night-shift workers. Industrial Health 49:589-596

33. Chang, L. R., Lin, Y. H., Kuo, T. B. J., Wu Chang, H. C., Liu, C. M., Liu, C. C., Hwu, H. G., and Yang, C. C. H.* (2011) Autonomic Modulation and Health-related Quality of Life among Schizophrenic Patients Treated with Non-intensive Case Management. PLoS ONE 6:e26378

34. Lin, Y. H., Kuo, T. B. J., Ho, Y. C., Lin, S. H., Liu, C. Y. and Yang, C. C. H.* (2012) Physiological and psychological impacts on male medical interns of on-call duty. Stress 15:21-30

35. Chen, P. L., Kuo, T. B. J., and Yang, C. C. H.* (2012) Parasympathetic activity correlates with early outcome in patients with large artery atherosclerotic stroke. Journal of the Neurological Sciences 314:57-61

36. Chang, L. R., Lin, Y. H., Kuo, T. B. J., Ho, Y. C., Chen, S. H., Wu Chang, H. C., Liu, C. M. and Yang, C. C. H.* (2012) Cardiac autonomic modulation during methadone therapy among heroin users: a pilot study. Progress in Neuro-Psychopharmacology and Biological Psychiatry 37:188-193

37. Chung, M. H., Kuo, T. B. J., Hsu, N., Chu, H., Chou, K. R. and Yang, C. C. H.* (2012) Recovery after three-shift work: relation to sleep-related cardiac neuronal regulation in nurses. Industrial Health 50:24-30

38. Wang, Y. C., Chen, C. Y., Kuo, T. B. J., Lai, C. J. and Yang, C. C. H.,* (2012) The influences of antipsychotic agents on the heart rate variability in male WKY rats: implications for cardiovascular safety. Neuropsychobiology 65:216-226

39. Huang, W. L., Lin, Y. H., Kuo, T. B. J., Chang, L. R., Chen, Y. Z. and Yang, C. C. H.* (2012) Methadone-mediated autonomic functioning of male patients with heroin dependence: the influence of borderline personality pattern. PLoS ONE 7:e37464

40. Kuo, T. B. J., Chen, C. Y., Hsu, Y. C. and Yang, C. C. H.* (2012) Performance of the frequency domain indices with respect to sleep staging. Clinical Neurophysiology 123:1338-1345

41. Huang, S. S., Su, H. H., Kuo, T. B. J., Chen, C. Y., Lan, Y. Y., Liu, B. Y., Young, D. I., Tsai, S. C. and Yang, C. C. H.* (2012) Suppressing cardiac vagal modulation and changing sleep patterns in rats after chronic ischemic stroke injury. Autonomic Neuroscience-Basic and Clinical 169:116-123

42. Ya-Chun Chua†*, Cheryl C. H. Yang†, Ho-Tien Lin, Pin-Tarng Chen, Kuang-Yi Chang, Shun-Chin Yang and Kuo, T. B. J. (2012) Neonatal nociception elevated baseline blood pressure and attenuated cardiovascular responsiveness to noxious stress in adult rats. International Journal of Developmental Neuroscience 30:421-426

43. Li, J. Y., Kuo, T. B. J., Hsieh, I. T. and Yang, C. C. H.* (2012). Changes in hippocampal theta rhythm and their correlations with speed during different phases of voluntary wheel running in rats. Neuroscience 213: 54-61

44. Kuo, T. B. J., Chen, C. Y., Lai, C. T., Chuan, T. Y., Wu, W. Y., Tsai, S. C. and Yang, C. C. H.* (2012) Sleep Disturbance among Spontaneously Hypertensive Rats is Mediated by an α1-Adrenergic Mechanism. American Journal of Hypertension 25:1110-1117

45. Wang, Y. P., Kuo, T. B. J., Lai, C. T., Lee, G. S. and Yang, C. C. H.* (2012) Effects of breathing frequency on baroreflex effectiveness index and spontaneous bbaroreflex sensitivity derived by sequence analysis. Journal of Hypertension 30:2151-2158

46. Chen H. C., Yang, C. C. H., Kuo, T. B. J., Su, T. P. and Chou, P.* (2012) Cardiac vagal control and theoretical models of co-occurring depression and anxiety: A cross-sectional psychophysiological study of community elderly. BMC Psychiatry 12:93

47. Hsieh, I. T., Yang, C. C. H., Chen, C. Y., Lee, G. S., Kao, F. J., Kuo K. L. and Kuo, T. B. J.* (2012) Uninterrupted wireless long-term recording of sleep patterns and autonomic function in freely moving rats. Journal of Medical and Biological Engineering 33:79-86

48. Huang, W. L., Chang, L. R., Kuo, T. B. J., Lin, Y. H., Chen, Y. Z. and Yang, C. C. H.* (2012) Impact of Antipsychotics and Anticholinergics on Autonomic Modulation in Patients with Schizophrenia. Journal of Clinical Psychopharmacology 33:170-177

49. Kuo, T. B. J., Lai, C. T., Chen, C. Y., Lee, G. S. and Yang, C. C. H.* (2012) Unstable sleep and higher sympathetic activity during late sleep periods of rats: implication for late sleep-related higher cardiovascular events. Journal of Sleep Research 22:108-118

50. Wang, T. S.,†, Huang, W. L.†, Kuo, T. B. J., Lee, G. S. and Yang, C. C. H.* (2012) Inattentive and hyperactive preschool-age boys have lower sympathetic and higher parasympathetic activity. Journal of Physiological Sciences 36:87-94

51. Lin, Y. H., Chen, C. Y., Lin, S. H., Liu, C. H., Weng, W. H., Kuo, T. B. J. and Yang, C. C. H.* (2013) Gender differences in cardiac autonomic modulation during medical internship. Psychophysiology 50:521-527

52. Huang, W. L., Chang, L. R., Kuo, T. B. J., Lin, Y. H., Chen, Y. Z., Yang, C. C. H.* (2013) Gender differences in personality and heart rate variability. Psychiatry Research 209:652-657

53. Liu, K. D., Shan, D. I., Kuo, T. B. J., Yang, C. C. H.* (2013) The effects of bilateral stimulation of the subthalamic nucleus on heart rate variability in patients with Parkinson’s disease. Journal of Neurology 260:1714-1723

54. Huang, S. S., Cheng, H., Tang, C. M., Nien, M. Y., Huang, Y. S., Lee, I. H., Yin, J. H., Kuo, T. B. J., Yang, C. C. H., Tsai, S. K.*, Yang, D.I.* (2013) Anti-oxidative, anti-apoptotic, and pro-angiogenic effects mediate functional improvement by sonic hedgehog against focal cerebral ischemia in rats. Experimental Neurology 247:680-688

55. Lin, Y. H., Ho, Y. C., Lin, S. H., Yeh, Y. H., Liu, C. Y., Kuo, T. B. J., Yang, C. C. H., Yang, A. C.* (2013) On-call duty effects on sleep-state physiological stability in male medical interns. Plos One 8:e65072

56. Chen, C. Y., Kuo, T. B. J., Hsieh, I. T., Yang, C. C. H.* (2013) Electrical stimulation of the rostral ventrolateral medulla promotes wakefulness in rats. Sleep Medicine 14:1076-1084

57. Wang, Y. P., Kuo, T. B. J., Lai, C. T., Chu, J. W., Yang, C. C. H.* (2013) Effects of respiratory time ratio on heart rate variability and spontaneous baroreflex sensitivity. Journal of Applied Physiology 115:1648-1655

58. Kuo, T. B. J., Li, J. Y., Lai, C. T., Huang, Y. C., Hsu, Y. C., Yang, C. C. H.* (2013) Effect of bedding system selected by manual muscle testing on sleep-related cardiovascular functions. Biomed Research International http://dx.doi.org/10.1155/2013/937986

59. Kuo, T. B. J., Chen, C. Y., Wang, Y. P., Lane Y. Y., Mak, K. H., Yang, C. C. H.* (2014) The role of autonomic and baroreceptor reflex control in blood pressure dipping and non-dipping in rats. Journal of Hypertension 32:806-816

60. Wang, Y. P., Kuo, T. B. J., Yang, C. C. H.* (2014) Reply to Hejjel. Journal of Applied Physiology 116:710

61. Li, J.-Y., Kuo, T. B. J., Yen, J.-C., Tsai, S.-C., Yang, C. C. H.* (2014) Voluntary and involuntary running in the rat show different patterns of theta rhythm, physical activity and heart rate. Journal of Neurophysiology 111:2061-2070

62. Kuo, T. B. J., Hong, C.-H., Hsieh, I.-T., Lee, G.-S., Yang, C. C. H.* (2014) Effects of cold exposure on autonomic changes during the last REM sleep transition and morning blood pressure surge in humans. Sleep Medicine 15:986-997

63. Wang, Y. B., Kuo, T. B. J., Yang, C. C. H.* (2014) A possible explanation for the effects of respiration on heart rate and blood pressure asymmetry. International Journal of Cardiology 174:805-807

64. Tsai, H. J., Kuo, T. B. J., Lee, G.-S., Yang, C. C. H.* (2015) Efficacy of paced breathing for insomnia: enhances vagal activity and improves sleep quality. Psychophysiology 52:388-396

65. Lin Y. H., Lin Y. C., Lee Y. H., Lin P. H., Lin S. H., Chang L. R., Tseng H. W., Yen L. Y., Yang C. C. H., Kuo T. B. J.* (2015) Time distortion associated with smartphone addiction: identifying smartphone addiction via a mobile application (App) Journal of Psychiatric Research 65:139-145

66. Huang W. L., Hwang B. T., Lai C. T., Li J. Y., Kuo T. B. J., Yang C. C. H.* (2015) Is heart rate variability related to season of birth? Clinical Cardiology 38:407-412

67. Wang, Y. B., Kuo, T. B. J., Lai C.T., Yang, C. C. H.* (2015) Effects of breathing frequency on the heart rate deceleration capacity and heart rate acceleration capacity. European Journal of Applied Physiology 115:2415-2420

68. Lai, C. T., Chen, C. Y., Kuo, T. B. J., Chern, C. H., Yang, C. C. H.* (2015) Sympathetichyperactivity, sleep fragmentation and wake-related blood pressure surge during late-light sleep in spontaneously hypertensive rats. American Journal of Hypertension 29:590-7

69. Tsai, H. J.†, Kuo, T. B. J., Lin, Y. C.†, Yang, C. C. H.* (2015) The association between prolonged sleep onset latency and heart rate dynamics among young sleep-onset insomniacs and good sleepers. Psychiatry Research 230:892-898

70. Kuo, T. B. J.†, Li, J. Y.†, Kuo, H. K., Chern, C. M., Yang, C. C. H.* (2016) Differential changes and interactions of autonomic functioning and sleep architecture before and after 50 years of age. Age 38:5

71. Kuo, T. B. J.†, Chen C. Y.†, Hsu, Y. C., Yang, C. C. H.* (2016) EEG beta power and heart rate variability describe the association between cortical and autonomic arousal across sleep. Autonomic Neuroscience: basic and clinical 194:32-7

72. Huang W. L., Liao S. C., Kuo, T. B. J., Chang, L .R., Chen, Z. T., Chen, I. M., Yang, C. C. H.* (2015) The effects of antidepressants and quetiapine on heart rate variability. Pharmacopsychiatry [Epub ahead of print]

73. Hong C. H. †, Kuo T. B. J. †, Huang B. C., Lin Y. C., Kuo K. L., Chern C. M., Yang C. C. H.* (2016) Cold exposure can induce an exaggerated early-morning blood pressure surge in young prehypertensives. PLoS One.11(2):e0150136

74. Lin, Y. C., Lin, Y. H., Lo, M Z., Peng, C. K., Huang, N. E., Yang, C. C. H., Kuo, T. B. J.* (2016) Novel application of multi dynamic trend analysis as a sensitive tool for detecting the effects of aging and congestive heart failure on heart rate variability. Chaos 26:023109

75. Kuo, T. B. J.†, Lai, C. T. , Chen, C. Y. †, Yang, Y. C., Yang, C. C. H.* (2016) The high-frequency component of heart rate variability during extended wakefulness is closely associated with the depth of the ensuing sleep in C57BL6 mice. Neuroscience 330: 257-66

76. Li, J. Y., Kuo, T. B. J., Yang, C. C. H.* (2016) Aged rats show the dominant modulation on lower frequency of hippocampal theta rhythm during running. Experimental Gerontology 83:63-70

77. Lin, W. L, Lo, L.W., Chen, H. R., Lai, C. T., Yamada, S., Liu, S. H., Chou. Y. H., Chen, S. A., Fu, Y. C., Kuo T. B. J.* (2016) Sleep-related changes in cardiovascular autonomic regulation in left coronary artery ligation rats: Neural mechanism facilitating arrhythmia after myocardial infarction. International Journal of Cardiology 225:65–72

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